an efficient radiosynthesis of 18f fluoromisonidazole



An efficient preparation of the hypoxic cell tracer [18F]3-fluoro-1-(2′-nitro-1′-imidazolyl)-2-propanol ([18F]fluoromisonidazole) is reported. This radiopharmaceutical is of interest to probe hypoxic tissue in infarcts and tumors. One-step radiolabeling and rapid protection group removal provided 55–80% yield in 50 min.
Appl Radiat Isot. 1993 Aug;44(8):1085-91. An efficient radiosynthesis of [18F]fluoromisonidazole. Lim JL(1), Berridge MS. Author information: (1)Department of Radiology, Case Western Reserve University, Cleveland, OH. An efficient preparation of the hypoxic cell tracer [18F]3-fluoro-1-(2'-nitro-1'-imidazolyl)-2-propanol
21:1234 (1984) Jerabek, P.A.; Patrick, T.B.; Kilbourn, M.R.; Dischino, D.D.; Welch, M.J.; Synthesis and Biodistribution of 18F-Labeled Fluoronitroimidazoles: Potential in vivo Markers of Hypoxic Tissue; Appl. Rad. Isot. 37 (7):599-605 (1986) Lim, J.L.; Berridge, M.S.; Efficient Radiosynthesis of [18F]-Fluoromisonidazole
Bioconjugate Chem 17: 68–76 LiZ-B, Chen K, Chen X (2008)68Ga-labeled multimeric RGD peptides for microPET imaging of integrin αv β3 expression. Eur J Nucl Med Mol Imaging 35: 1100–1108 Lim JL, Berridge MS (1993) An efficient radiosynthesis of [18F]fluoromisonidazole, Appl Radiat Isot 44:1085–1091 Lidström P,
Ty - jour t1 - radiosynthesis of [ 18f]fluoromethyldeoxyspergualin for molecular imaging of heat shock proteins au - ghosh,pradip au - li,king c. An efficient preparation of the hypoxic cell tracer [18f]3-fluoro-1-(2'-nitro-1'-imidazolyl)-2-propanol ([18f]fluoromisonidazole) is reported this radiopharmaceutical is of interest. Efficient
J Nucl Med 30:343–350 McCarthy TJ, Dence CS, Welch MJ (1993) Application of microwave heating to the synthesis of [18F]fluoromisonidazole. Appl Radiat Isot 44:1129–1132 Lim J-L, Berridge MS (1993) An efficient radiosynthesis of [18F]fluoromisonidazole. Appl Radiat Isot 44:1085–1091 Patt M, Kuntzsch M, Machulla
Endocr Relat Cancer 16:255–265 Kawaguchi M, Tateishi U, Shizukuishi K, Suzuki A, Inoue T (2010) 18F-fluoride uptake in bone metastasis: morphologic and metabolic analysis on integrated PET/CT. Ann Nucl Med 24:241–247 Kawai ... An efficient radiosynthesis of [18F]fluoromisonidazole. Appl Radiat Isot 44:1085–1091
KWON, Young-Do et al. Facile and Efficient Synthesis of [18F]Fluoromisonidazole Using Novel 2-Nitroimidazole Derivatives. []. , 27, 7, pp.1150-1156. ISSN 0103-5053. dx.doi.org/10.5935/0103-5053.20160010. [18F]Fluoromisonidazole ([18F]FMISO) is a hypoxia imaging marker utilized in positron emission
Facile and Efficient Synthesis of [18F]Fluoromisonidazole Using Novel 2-Nitroimidazole Derivatives. Young-Do Kwon. Yongju Jung. Seok Tae Lim. Myung-Hee Sohn. Hee-Kwon Kim. aDepartment of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Biomedical Research Institute, Chonbuk
[18f]fluoromisonidazole, [18f]fmiso frequently asked questions an efficient radiosynthesis of [18f]fluoromisonidazole appl radiat isot 44, 1085-1091. An efficient radiosynthesis of [18 f]fluoromisonidazole appl radiat (fluoromisonidazole and positron emission tomography j nucl med 1992, 33, 2202-2208.

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